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Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

Innate Repair Receptor (IRR) Activation: ARA-290 binds selectively to the IRR (EPOR/CR heteromer), activating the full IRR-mediated tissue protection cascade: JAK2/STAT3, PI3K/Akt, and MAPK/ERK signalling, producing anti-apoptotic, anti-inflammatory, and regenerative downstream effects across neural, vascular, and metabolic cell types

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Journal of PhysiologyPharmacology , 2009 Pairing with TB-500 or CJC-1295 may further enhance repair speed and reduce inflammation